EVALUATION OF ECONOMIC FEASIBILITY OF CANCER PREVENTION BY VACCINATION FROM PAPILLOMAVIRUS INFECTION IN UKRAINE

Анотація

Infection with human papillomavirus (HPV) presents a serious problem for modern healthcare. The most common manifestations of the papillomavirus infection include anogenital warts, cervical intraepithelial neoplasia, cervical cancer. The purpose of the work is to determine the economic feasibility of preventing cervical cancer in Ukraine by introducing a continuous vaccination against a papilloma virus infection. Markov simulation was used to determine the incremental cost-effectiveness ratio (ICER) based on epidemiological data on morbidity and mortality from cervical cancer in Ukraine. Taking into account the accepted assumptions and limitations of the introduction of HPV vaccination in Ukraine, it will prevent 1380 cervical cancer cases, preserve 2058 quality-adjusted life years and the reduce the cost of medical care for cervical cancer in the amount of $1,479,972. The amount of additional costs for the vaccine and its introduction is $12,009,684 (all results per 100,000 vaccinated persons). The ICER index is $4,729, which is 1.4 times higher the gross domestic product in Ukraine per 1 person in 2019 ($3,464). Taking into account the actual cost of the vaccine, vaccination against HPV infection with a view of preventing cervical cancer in Ukraine is currently economically feasible.

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