The influence of the patients' participation in trials on the adherence to treatment in future

Анотація

The aim of the study was to estimate the influence of participation in trials on the adherence of the patients to the treatment of chronic obstructive pulmonary disease (COPD) and concomitant arterial hypertension (AH) after the trial finishing. 43 patients (average age 51,5±6,5 years) with severe and very severe COPD and concomitant moderate AH were enrolled. On the each visit patients received information about the necessity of the regular taking of the basis therapy of the main and concomitant disease. The duration of the trial visits were 160±32 minutes instead of 21±5 minutes in case of routine ambulatory visits. Patients filled diaries concerning their knowledge about COPD and AH, taking of the basis therapy of both diseases. The statistical program SPSS 16.0 used for working with the data of study. It was revealed that before the trial only 22 (51%) of the patients had basis therapy due to COPD and only 18 (42%) of them took antihypertensive therapy regularly. In the 6 months after the trial completing these data were 38 (88%) and 37 (86%) respectively. Patients answered that their knowledge about COPD and AH grows on 75±9%. The patients had 1,1±0,2 COPD exacerbations during the 6 months before the trial and during the next 6 months after the trial completing they had 0,7±0,1 COPD exacerbations (p=0,041). Perhaps, the improvement of the patients9 adherence to the treatment of COPD and AH connected with better cooperation between the patient and investigator than it was in routine clinical practice. Conclusions. The participation in trial due to COPD improves the adherence of patients to the treatment of COPD on 37% and AH on 44% after the trial completion.

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