POSSIBILITY OF BLOOD PRESSURE CONTROL BY UKRAINIAN GENERIC DRUGS IN DIABETIC HYPERTENSIVE PATIENTS IN PRIMARY CARE SETTING: RESULTS OF MULTICENTRE OPEN TRIAL: PP.17.128

Анотація

The aim of this study was to compare diabetic and non diabetic hypertensive patient characteristics and to evaluate the possibility of BP control by Ukrainian generic drugs in dependency from diabetes presence. 10158 patients (12,7% with new diagnosed hypertension) with BP > 140/90 mmHg were included in 3 mth multicentre (62 towns and 531 primary care physicians) open trial. All patients were divided in 2 groups: 1st – 1208 with DM type 2; 2nd – 8950 without DM. Patients were treated by primary care physician, who prescribed mostly the Ukrainian generic drugs for achieving target BP. Baseline patients with DM had higher systolic and diastolic BP, more percentages of complications, CAD, risk factors and were less educated. Drug compliance was lower in DM patients baseline and at the end of study. Patients with obesity (P < 0.001) and low physical activity (P < 0.005) had significant higher percentage of DM, than patients without obesity and higher physical activity – 19.9, 12.7% and 9.1, 10.7% respectively. BP decreased significantly (P < 0.001) in both groups from 171.3 ± 0.73/98.6 ± 0.3 and 165.5 ± 0.27/96.4+/0.14 mmHg to 137.5 ± 0.39/82.9 ± 0.24 and 134.3 ± 0.19/81.3 ± 0.15mmHg respectively in 1st and 2nd groups. But the level of BP in DM patients was higher than in non DM. The BP<140/90mmHg was achieved in 54.7% of DM patients and in 71.8% without DM (P < 0.001). The level <130/80mmHg was achieved only in 16.4% DM patients. Predictors of poor BP in DM hypertensives were older age, higher BMI, complications (stroke, heart failure, retinopathy), CAD, family cardiovascular disease history, baseline high BP level, low drug compliance, low physical activity, low consumption of fresh vegetables or fruits. Higher BP was in patients with lower doses of antihypertensive drugs and with rare using of combinative therapy. DM hypertensive patients were more severe group, than patients without DM. It was harder to achieve target BP in them. For better BP control there were necessary to provide more intensive therapy and life style modification, improve of drug compliance.

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